Immunology Mcqs-i (gate Helpline)

GATE HELPLINE IMMUNOLOGY MCQs-I

1) Which of the following terms are true about B and T cells recognition of antigen? a) B cell only recognizes antigen presented by class I or class II MHC molecules. b) Both cell types can be recognize antigen in solution (without cells) c) Both cell types recognize extracellular matrix bound antigens. d) T cells only recognize antigen presented by class II or class I MHC molecules 2) From the third to seventh months of gestation hematopoiesis in fetal takes place at a) Liver c) bone marrow b) Spleen d) thymus 3) The average life span of a erythrocyte is a) 60 days c) 240 days b) 120 days d) 480 days 4) ASSERTION (A): SCID mice are used in invivo assay system for the presence and function of HSCs. REASON(R): SCID does not have B and T lymphocytes and are unable to mount adaptive immune response. a) A is correct, R is wrong b) A is wrong, R is correct c) Both A and R are correct d) Both A and R are wrong 5) Lymphoid cells constitutes a) Macrophages, Mast cells, and NK cells b) B cell, Tcell and NK cells c) Neutrophiles, basophiles and eosinophiles d) B cell, T cell and dendritic cells 6) Which of the following is called polymorphonuclear (PMN)? a) Neutrophile c) eosinophiles b) Basophile d) mast cells 7) i. Acute phase protein detecting infection site ii. C- reactive protein psoriasin iii. Antimicrobial protein defensins iv. Antimicrobial peptide mannose binding lectin v. NOD protein pentraxins a) v , iii, iv, i, ii c) i , iii, ii, v, iv b) v, iii, ii, iv,i d) iii, iv, v, i, ii

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8) Which of the following is not related with Adjuvants? a) Antigens persistence is prolonged b) Costimulatory signals are enhanced c) Local inflammation is increased d) Specific proliferation of lymphocytes is stimulated 9) Granuloma is rich in a) Mast cells c) neutrophiles b) Macrophages d) natural killer cells 10) Which of the following enzymes mediates both somatic hypermutation and class switching? a) Recombinase c) TdT b) Activation induced cytidine deaminase d) none of the above 11) Generation of combinatorial diversity among immunoglobulin involves a) mRNA splicing c) switch sites b) DNA rearrangement d) one turn/two turn joining rule 12) Kappa and lambda light chain genes a) Are located on the same chromosome b) Associated with only one type of heavy chain c) Can be expressed by same B cell d) All of the above 13) Recombination of immunoglobulin gene segments serves to a) Promotes Ig diversification b) Assemble a complete Ig coding sequence c) Allow changes in coding information during B cell d) All of the above 14) Somatic mutation of immunoglobulin gene accounts for a) Allelic exclusion b) Class switching from Ig M to Ig G c) Affinity maturation d) All of the above 15) The frequency of somatic mutation in Ig gene is greatest during a) Differentiation of the pre-B cells into mature B cells b) Differentiation of the pre- T cell into mature T cells c) Generation of memory B cells d) Antibody secretion by plasma cells. 16) Polysaccharides can bind and activate a) B cell only c) both B cell and T cell b) T cell only d) none of the above This is copyrighted product of Gate helpline

17) Which of the following immune cells secretes interleukin-2? a) Macrophage c) B cell b) T cell d) none of the above 18) Which of the following antigen have many epitopes but different from each other? a) Polysaccharide c) protein b) Hapten d) lipids

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