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Your Genes, Your Choices: by Catherine Baker Exploring the Issues Raised by Genetic Research
New Genetics: One way to explore the topic of new
genetics and genetic research is to look at it in terms of the ethical, legal, and social issues. Ethical issues concern what is moral or right. Legal issues concern the protections that laws or regulations should provide. Social issues concern how society as
Genetic Testing In the past few years researchers
have increased their knowledge to test for hundreds of genetic disorders More new tests are established all the time Tests are helpful for diagnosing disorders in the young and adults Tests are also useful in predicting chances for an individual to come
Continue... They are also used by couples who
want to learn their risk of passing on genetic disorders to any children they may have. Prenatal tests are done before birth to an embryo or foetus, to check for genetic problems Test results can be definite but in other cases they only suggest the risk for developing a disorder.
Continue... One way of testing is to do a
medical exam A person’s family history is studied using for example, pedigree, for clues as to how the disorder has been passed down from generation to generation. A blood sample can be obtained in order to look at a person’s chromosomes.
Concerns About Genetic Testing Great progress is been made in
genetic testing but it is slower in the treatment of genetic disorders Tests are available to give results but treatment is lacking e.g.. Huntington Disease
Genetic Counselling: It is a medical speciality that helps
parents and prospective parents evaluate and cope with their risk of passing a hereditary disorder to their children It is important for anyone wanting to obtain information about their genes
Continue... With counselling from professional
advisors, people can understand the facts of their situation Counsellors can help in understanding the limitations of the tests and how different test results might affect them Counsellors can explain to people what their choices are after they know the results
Continue... Genetic counselling is a new field
and there’s a small number of trained genetic counsellors New tests are coming out faster than new counsellors are been trained
Genetic Determinism:
Genes have something, but not
everything, to do with disorders Misunderstanding that genes by themselves determine what happens to you is called genetic determinism It can lead people to harmful and unfair judgements about themselves and others
Dealing with Genetic Knowledge
Decisions we make on how to live
our lives will be influenced by information we have about our genes Knowing one’s genetic profile is helpful: Suggests what health-related
Continue... Tips you off to have frequent
checkups for genetic conditions Helps to plan life by avoiding behaviours and substances that trigger disease Knowing one’s genetic profile can create problems: Everyone has a number of problem genes that they don’t know about until a health problem surfaces
Continue... A piece of paper listing “problem”
genes could give a lot to worry about People tend to limit their choice based on fears People may choose not to marry or build a career because of their “problem” gene or genetic profile
A Big Question! ! ! Whether children should be told
information about the genes they carry or, if so, at what age they should be told It is difficult for children to understand facts about genetics such as the difference between a risk and a sure thing There’s a possibility of misunderstanding what they are told
Discrimination Based on Genes Information about “problem” genes
can bring extra trouble e.g. Cost of health insurance People with “problem” genes have been denied health insurance or dropped from their health plans. Medical expanses are not covered due to genetic conditions
Continue... People have been told that their
children will not be covered because they are at risk for inheriting genetic disease Number of such cases may increase as genetic testing becomes more common Some people are concern that employers may use genetic information to weed out workers who
Continue... The fear of being discriminated
against may lead people to refuse genetic testing even when it could help diagnose, prevent or treat a health problem They may be too afraid that the information will be used against them; If that happens, then all the benefits of genetic research could come to nothing.
Genes and Behaviour The study of whether and how traits
for behaviour are inherited is called behavioural genetics Scientists have long tried to figure out whether behaviour is shaped by our genes or by how we are raised. It is called the question of “nature versus nurture”
Continue... Scientists agree that both genes
(nature) and environment (nurture) help make us who we are What no one knows is just how nature and nurture work together Researchers believe that genes shape our inborn frame of mind or temperament
Prenatal Tests: Types
I. Alpha-fetoprotein test (AFP) A sample of the mother’s blood is
taken to measure the amount of a special protein produced by the foetus Too much or too little of the protein indicates that the genes may not be working right Therefore, the brain or spine of the
Continue... 1. Enzymes Foetal cells are checked for
presence of important enzymes Some diseases are caused when the gene that gives the instructions for producing an enzyme doesn’t work If the production of the enzyme ceases, an important body function stops and this results into a disease
Continue... 3. Ultrasound imaging Ultrasound uses sound waves to create an image of the baby inside the mother 4. Amniocentesis (called “amnio” for short) and chorionic villus sampling (CVS) These are tests that check for defects in the chromosomes Cells surrounding the foetus are
Continue... A special technique is used to
rearrange the chromosomes into pairs. The picture that is created is called a karyotype which makes it easy to see if any chromosomes are missing or broken, or if there are any extra chromosomes
Reproductive Technology
Advances in prenatal testing have
come hand in hand with advances in medically assisted ways of making babies; reproductive technology Is often used to help people who have problems conceiving children Also is used to help people reduce their risk of having babies with
Continue… Types: 2. Artificial Insemination 3. In vitro fertilization 4. Ex utero genetic testing
DNA Typing: First introduced in the early 1980s Turns DNA sample into a set of lines The lines of one DNA sample can be
compared to the lines of another sample to see if they are alike A match between two samples can be made only if entire DNA sequences are compared Hair, blood, saliva, semen, skin, and nail clippings, because they all are
Uses For DNA Typing: For identifying bodies; because DNA
lasts longer To tell whether two people come from the same family Gender identification and other physical characteristics
Continue… To prove innocence To prove guilt To identify relatives To prove fatherhood To identify bodies To identify soldiers To uncover history To study human evolution
Issues of Computers can store information Privacy from millions of DNA samples They can rapidly search through all
of this information to find matches Searching is done in the DNA data bank where the samples are stored Every time the police search their computer to find a match for some DNA evidence found at some crime scene, they are checking someone’s DNA without permission
Continue… Owners of DNA samples are being
made permanent suspects, which means that their privacy is invaded Privacy is the “right to be left alone” or “the right to decide for yourself what information others can know about you.” Also is the right to decide what information you learn about yourself
Controls on DNA Files: DNA information could end up in other
types of data banks Personal and medical information is released in most cases such as, applying for a job, life or health insurance, credit, financial aid, or government benefits If the results of any DNA tests become part of your records, you may have to release the information in order to obtain needed services.
Continue… There are no laws concerning DNA
data banks No law which says that a blood sample collected for one kind of DNA testing can’t be used for another purpose No law that limits data bank employees from snooping in your files No law that gives you the right to check your DNA file to find out what
Eugenics: The word "eugenics" was coined by
Sir Francis Galton (1822-1911) to denote scientific endeavors to increase the proportion of persons with better than average genetic endowment through selective mating of marriage partners Is the science which deals with all influences that improve the inborn qualities of a race; also with those that develop them to the utmost advantage (THE AMERICAN JOURNAL OF SOCIOLOGY
Continue… Also defined as the use of genetic
knowledge to improve the human race