Tahbso Pathophysiology

HOST 39 female HFD of cancer (CA of liver) High fat diet Hx of dysmenorrheal High estrogen levels

AGENT Altered Cell Differentiation and Growth

ENVIRONMENT

tumor in the ovary -germ cell ovary tumors -epithelial cell tumors -sex cord stromal ovarian tumor (granulosa cell tumor)

staphylococcus, streptococcus, coliform bacteria invasion to the lacerations that occur during childbirth, instrumentation or trauma

Stimulation of the growth of leiomyomas Enlargement of ovary

low grade inflammation Wall of Bladder under rectum leiomyomas fluid accumulates compression uterus lining without in the abdomen of stomach of uterus symptoms (ascites) urinary frequency/ heavy urgency bleeding abdominal impaired loss of appetite abnormal distention/ functioning constipation presentation bloating of lower of baby esophageal miscarriage before sphincter malabsorption delivery diaphragm of Fe dysmenorhhea pushed upward acid, enzyme malabsorption and gastric of vit. B12 content reflux pressure exerted to the lungs heartburn Hgb MCV MCH (9.49 g/dl) (71.6 fl) (23.1 pg) alteration in the permeability of pleural membrane esophagitis affinity of RBC to 02

ducts of glands in distorted cervix are blocked cervical by a new growth os of surface cells over damaged area ulcerated cervix formation of sac that contains thick fluid nabothian cyst

untreated

dysmenorrheal dyspnea SOB chest pain

accumulation of fluid in the pleural cavity fatigue hypoxemia pallor pale (pleural effusion) nailbeds

pale palpebral conjunctiva

mucopurulent drainage

low back pain stenosis

pelvic cellulitis dyspaneuria

cervical

inadequate tissue perfusion hypoxia

dilation of arterioles, capillaries and venules (compensatory mechanism)

irritability, LOC, cyanosis, seizures, coma (compensatory mechanism)

movement of fluid from interstitial to blood vessels (compensatory mechanism) expansion of blood volume blood viscosity

faster and more turbulent blood flow BP (compensatory mechanism)

uncontrolled BP SGOT

hepatic perfusion pancreatic perfusion

SGPT RUQ epigastric pain hyperbilirubinemia jaundice

renal perfusion

vasospasm

Hct (29.4 %)

GFR

Permeability of glomerular membrane

BUN,

serum creatinine

Na retention

oliguria

large protein particles primarily albumin move out of urine

remaining functional nephrons compensate by more filtration

hypertrophy of functional nephrons further damage of nephrons

serum albumin

proteinuria multi-system manifestations/uremic syndrome

plasma colloid osmotic pressure movement of fluid from intravascular to interstitial

immune disturbances intravascular volume in lungs

loss of excretory renal function

failure to produce erythropoietin

generalized edema further anemia cerebral edema

pulmonary edema (pleural effusion)

impair wound healing

CNS irritability Na absorption

impaired gas exchange

nausea

vomiting

convulsion

influx of excess Na in urine (salt wasting)

H secretion metabolic acidosis

phosphate excretion hyperphosphatemia

K excretion

excretion of nitrogenous wastes

hypokalemia uremia

hypoxemia hypoatremia

Ca absorption

excitability of heart muscles

hypoxia

BUN, uric acid, creatinine

ECF becomes hyposmolar release PTH tissue necrosis water rushes inside cell

parathyroid gland heart muscles become weak, flaccid and paralyzed

pruritus

phosphate excretion absorbs Ca from bones

bleeding tendencies fluid loss in ECF DEATH

cardiac arrest

peripheral nerve damage

bone demineralization circulating fluid in systemic circulation O2 supply to tissue

Neurologic changes

calcification of vital hypovolemic shock

organs tissue necrosis Coma

further exposure of brain to nitrogenous wastes

peripheral neuropathy