Hemass

Tissue factor Which of the following initiates in vivo coagulation by activation of factor VII?

It is required for carboxylation of glutamate residues of some coagulation factors Which of the following characterizes vitamin K?

Plasmin activator

Its activity is enhanced by heparin therapy

Thrombomodulin

It is required for carboxylation of glutamate residues of some coagulation factors

Protein C It is required for biological activity of fibrinolysis Tissue factor Sodium citrate The anticoagulant of choice for most routine coagulation studies is:

It is made by the endothelial cells XII, XI, IX, VIII, X, V, II, I Which of the following clotting factors are measured by the APTT test?

Ethylenediaminetetraacetic acid (EDTA) XII, VII, X, V, II, I Sodium citrate II, VII, IX, X Heparin XII, XI, IX, VIII, X, V, II, I Sodium oxalate 1:9 Which ratio of anticoagulant-to-blood is correct for coagulation procedures?

VII, X, V, II, I PT and APTT Which coagulation test(s) would be abnormal in a vitamin K-deficient patient?

1:5 PT and APTT 1:10 Fibrinogen level 1:4 Thrombin time 1:9 PT and APTT Which test would be abnormal in a patient with factor X deficiency?

PT only It standardizes PT results Which of the following is correct regarding the international normalized ratio (INR)?

PT and APTT It standardizes PT results PT only It is used to monitor heparin therapy APTT only It standardizes APTT results Thrombin time Factor XIII Which clotting factor is not measured by PT and APTT tests? Factor XIII Factor VIII

It uses the International Sensitivity Ratio (ISR) Reject the sample and request a new sample A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the following morning for a tonsillectomy. Which of the following is the necessary course of action by the technologist?

Factor V Report the PT result Factor IX Report the APTT result

levels Run both tests in duplicate and report the average result Reject the sample and request a new sample Increased platelet aggregation and clotting Thrombotic thrombocytopenic purpura (TTP) is characterized by:

Bleeding time Thrombocytopenia and giant platelets Bernard-Soulier syndrome is associated with: Thrombocytopenia and giant platelets Decreased factor VIII assay

Increased platelet aggregation and clotting Decreased bleeding time Thrombocytosis Prolonged PT Prolonged APTT Hypersplenism Thrombocytopenia may be associated with: Hypersplenism

Abnormal platelet aggregation to ADP Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and epinephrine Which set of platelet responses would be most likely associated with Glanzmann's thrombasthenia? Normal platelet aggregation to ADP and ristocetin; decreased aggregation to collagen

Increased proliferation of pluripotential stem cells Acute blood loss Postsplenectomy Cyclo-oxygenase Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?

Normal platelet aggregation to collagen; decreased aggregation to ADP and ristocetin Normal platelet aggregation to ADP; decreased aggregation to collagen and ristocetin

Cyclo-oxygenase

Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and epinephrine Spontaneous remission within a few weeks Which of the following is a characteristic of acute immune thrombocytopenic purpura?

Prostacyclin sythetase

Insidious onset

Phospholipase Glycoprotein Ib Normal platelet adhesion depends upon:

Spontaneous remission within a few weeks

Glycoprotein Ib

Nonimmune platelet destruction APTT is normal in TTP but prolonged in DIC TTP differs from DIC in that:

Thromboxane A2 synthetase

Fibrinogen Calcium Glycoprotein IIb, IIIa complex Platelet count Which of the following test results is normal in a patient with classic von Willebrand's disease? Activated partial thromboplastin time Platelet count Factor VIII:C and von Willebrand's factor (VWF)

Predominantly seen in adults

Schistocytes are not present in TTP but are present in DIC PT is prolonged in TTP but decreased in DIC APTT is normal in TTP but prolonged in DIC Platelet count is decreased in TTP but normal in DIC Escherichia coli 0157:H7 Hemolytic uremic syndrome (HUS) is associated with:

Fever, thrombocytosis, anemia, and renal failure

XI

Escherichia coli 0157:H7

VIII

Leukocytosis and thrombocytosis Fever, granulocytosis, and thrombocytosis Platelet granules Storage pool deficiencies are defects of:

X IX A prolonged APTT is corrected with factor VIIIdeficient plasma but not with factor IX-deficient plasma. Which factor is deficient?

Platelet production

VIII

Platelet adhesion

X

Platelet aggregation

IX

Platelet granules Autoimmune disease Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?

V Mild to severe bleeding episodes Which of the following is a characteristic of classic hemophilia A?

Decreased VWF

Mild to severe bleeding episodes

Decreased platelet aggregation

Prolonged PT

Decreased platelet adhesion

Autosomal recessive inheritence

Autoimmune disease Prostacyclin Which of the following prevents platelet aggregation?

Prolonged bleeding time DIC Refer to the following results: PT = prolonged APTT = prolonged Platelet count = decreased Which disorder may be indicated?

Thromboxane B2 Antithrombin

von Willebrand's disease Thromboxane A2 Factor VIII deficiency Prostacyclin Factor X The APTT is sensitive to a deficiency of which clotting factor?

Factor IX deficiency

Factor X

DIC Increased risk of thrombosis Factor XII deficiency is associated with:

Calcium

Epistaxis

PF3

Bleeding episodes

Factor VII X Which factor deficiency is associated with a prolonged PT and APTT?

Increased risk of thrombosis

IX

Decreased risk of thrombosis Hemophilia A The following results were obtained on a patient: normal platelet count and function, normal PT, and

prolonged APTT. Which of the following disorders is most consistent with these results? Bernard-Soulier syndrome von Willebrand's disease

Dysfibrinogenemia Lupus anticoagulant Factor XIII deficiency Normal PT and APTT results in a patient with a poor wound healing may be associated with:

Glanzmann's thrombasthenia Factor XIII deficiency Hemophilia A Hypofibrinogenemia The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; thrombin time = 18 sec. What is the most probable diagnosis? Factor VIII deficiency

Factor VII deficiency Factor VIII deficiency Factor XII deficiency Hemarthrosis One of the complications associated with a severe Hemophilia A is:

Factor VII deficiency Immune-mediated thrombocytopenia Hypofibrinogenemia Hemarthrosis Factor X deficiency von Willebrand's disease Refer to the following results: PT = normal APTT = prolonged Bleeding time = increased Platelet count = normal Platelet aggregation to ristocetin = abnormal Which of the following disorders may be indicated?

Mucous membrance bleeding Mild bleeding during surgery Type 1 The most common subtype of classic von Willebrand's disease is: Type 1

Factor IX deficiency

Type 2A

Factor VIII deficiency

Type 2B

DIC von Willebrand's disease Prolonged APTT, normal PT Which results are associated with hemophilia A?

Type 3 V A prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?

Prolonged APTT, normal PT

VIII

Prolonged PT, and APTT

XI

Prolonged PT, normal APTT

IX

Normal PT and APTT Severe liver disease Which of the following is associated with multiple factor deficiencies?

V Thrombin time Which laboratory test is affected by heparin therapy?

Severe liver disease

Fibrinogen assay

An inherited disorder of coagulation

Protein C assay

Prothrombin time Thrombin time Protein S assay PT, APTT, TT A 50-year-old man has been on heparin for the past 7 days. Which combination of the tests is expected to be abnormal?

Platelet morphology Deactivation of factor Va Factor V Leiden promotes thrombosis by preventing: Activation of protein S

APTT, TT only

Activation of protein C

PT and APTT only

Activation of factor V

APTT, TT, fibrinogen assay

Deactivation of factor Va Hemophilia A Which of the following is the most prevalent inherited bleeding disorder?

PT, APTT, TT APTT What test is used to monitor hepatin therapy?

Factor XII deficiency INR Hemophilia B PT Factor VII deficiency APTT TT INR What test is commonly used to monitor warfarin therapy?

Hemophilia A thrombocytes Which of the following peripheral blood cells is involved in hemostasis? thrombocytes

APTT lymphocytes TT erythrocytes Ecarin time INR Va and VIIIa What clotting factors (cofactors) are inhibited by protein S?

granulocytes Factor VII Which factor is used only in the extrinsic coagulation pathway? Factor V

VIII and IX Factor VIII V and X Factor II Va and VIIIa VIII and X Bleeding time Which of the following tests is most likely to be abnormal in patients taking aspirin?

Factor VII Vitamin K synthesis Long-term antibiotic therapy is a cause of bleeding because it disrupts: Vitamin K synthesis

Platelet count Platelet aggregation Bleeding time Contact activation

Fibrinolytic activity Inhibits thrombin Heparin: Inhibits PF3

Prevention of thrombotic events Coagulation inhibition aPTT Which of the following assays will be abnormal with hemophilia A?

Inhibits thrombin blood vessel function Complexes with protein C aPTT Degrades antithrombin Factor Assays Which of the following is the most useful in differentiating hemophilia A from hemophilia B? Patient's history

PT Platelet count 1.Chediak-Higashi Syndrome Patients have alvinism and giant granules in neutrophils with impaired platelet release

A familial pattern of inheritance 1.Chediak-Higashi Syndrome Factor assays 2.Gray platelet Syndrome Activated partial thromboplastin time X and II Which factors are part of the common coagulation pathway?

3.Thrombocytopenia with absent radii (TAR) 3.Thrombocytopenia with absent radii (TAR) Rare disorder of skeletal system where patients have no radial bones

X and XII 1.Chediak-Higashi Syndrome X and II 2.Gray platelet Syndrome X and XIII VII and X 30% Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

3.Thrombocytopenia with absent radii (TAR) 2.Gray platelet Syndrome Platelets lack alpha granules and are larger and gray or blue-gray in color. 1.Chediak-Higashi Syndrome

Question options: 2.Gray platelet Syndrome 20%

50%

3.Thrombocytopenia with absent radii (TAR) Occurs 5 to 14 days after heparin therapy Heparin-induced thrombocytopenia (HIT) usually: Occurs as a result of protein C deficiency

75% Occurs 5 to 14 days after heparin therapy 30% Fibrin breakdown The primary role of plasmin is: Platelet aggregation Fibrin breakdown

Will show an increase in platelets Occurs only in males XIII Which factor is not measured by the PT or aPTT test?

XIII aPTT XII X VII Deep vein thrombosis D-dimers may be elevated in which of the following:

PT fibrinolysis Clot removal is accomplished by which of the following systems? anticoagulation

Glanzmann's thrombasthenia

hemostasis

Sickle cells disease

fibrinolysis

Deep vein thrombosis

thrombosis Factor-deficient plasma Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

Bernard-Soulier syndrome Cardiovascular disease All of the following may lead to deficiencies of clotting factors except:

Adsorbed plasma

Autoimmune disease

Factor-specific plasma

Cardiovascular disease

Normal plasma

Renal disease

Factor-deficient plasma It is associated with postpartum women, previous viral infections or gastric carcinomas In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

Liver disease adhesion of platelets An essential requirement for adequate primary hemostasis is:

The organ most affected is the kidney. presence of vitamin K retraction of the clot

It is associated with postpartum women, previous viral infections or gastric carcinomas

formation of a thrombus

More males are affected than females.

adhesion of platelets The platelet plug is formed. Primary hemostasis refers to the process by which: platelets are destroyed

It is associated with E. coli O157:H7 Bernard-Soulier syndrome The presence of thrombocytopenia and giant platelets on the peripheral smeal of a patient is characteristic of:

The platelet plug is formed.

Bernard-Soulier syndrome

A cross-linked fibrinolytic system

Hemophilia A

Fibrin degradation products are generated aPTT Which of the following is the most accurate coagulation test used to monitor heparin therapy?

Glanzmann's thrombasthenia

platelet count

Classic von Willebrand's disease ITP The disease in which platelets are destroyed by antibodies is:

bleeding time

ITP

TIP

Glanzmann's thrombasthenia

von Willibrand's disease

Gray platelet syndrome

DIC Normal platelet aggregation Which platelet response(s) is usually associated with hemophilia A?

Bernard-Soulier syndrome Factor XIII Which factor is also known as fibrin stabilizing factor?

Normal platelet aggregation

thrombin

Defective ADP release; normal response to ADP

prekallekrein

Absent aggregation to epinephrine, ADP, and collagen

Factor XIII

Decreased amount of ADP in platelets Deep muscle hemorrhages All of the following are associated with platelet disorders except:

Factor IV interaction of clotting factor Which of the following is NOT part of primary hemostasis? platelet aggregation

Abnormal platelet morphology interaction of clotting factor Epistaxis and menorrhagia platelet adhesion Deep muscle hemorrhages Thrombocytopenia VIII If the aPTT is polonged but the PT is normal, which of the following factors is most likely deficient?

vasoconstriction 1.Factor I fibrinogen 1.Factor I

VIII

2.Factor II

X

3.Factor III

VII

4.Factor IV

II Greater than 450 x 109/L Thrombocytosis is defined as a platelet count that is:

5.Factor V

Less than 450 x w109/L

6.Factor VII 7.Factor VIII 3.Factor III thromboplastin

Greater than 600 x 109/L 1.Factor I Less than 300 x 109/L 2.Factor II Greater than 450 x 109/L Gray platelet syndrome A platlet release defect in which there is a severe lack of alpha granules in platelets is known as: Chediak-Higashi syndrome

3.Factor III 4.Factor IV 5.Factor V

6.Factor VII

2.Factor II

7.Factor VIII 5.Factor V labile factor

3.Factor III

1.Factor I

5.Factor V

2.Factor II

6.Factor VII

3.Factor III 4.Factor IV

7.Factor VIII 7.Factor VIII antihemophilic factor

5.Factor V

1.Factor I

6.Factor VII

2.Factor II

7.Factor VIII 6.Factor VII proconvertin or stabile factor

3.Factor III

1.Factor I

5.Factor V

2.Factor II

6.Factor VII

3.Factor III 4.Factor IV

7.Factor VIII a gragment of the cytoplasm of a megakaryocyte Which of the following is true about platelets?

5.Factor V

production is controlled by erythropoietin

6.Factor VII

normal count is about 50 x 109/L

7.Factor VIII 4.Factor IV calcium

are made n the spleen

1.Factor I

4.Factor IV

4.Factor IV

a gragment of the cytoplasm of a megakaryocyte von Willebrand's disease and Bernard-Soulier Which of the following are platelet adhesion disorders?

2.Factor II 3.Factor III 4.Factor IV

von Willebrand's diease and Glanzmann's thrombasthenia Glanzmann's thrombasthenia and congenital fibrinogenemia

5.Factor V von Willebrand's disease and Bernard-Soulier 6.Factor VII 7.Factor VIII 2.Factor II prothrombin

Glanzmann's thrombasthenia and HermanskyPudlak syndrome Inherited - sex linked recessive Hemophilia A and B are:

1.Factor I

Acquired coagulation defect

The organ most affected is the spleen. Inherited - autosomal dominant Platelets are permanently impaired Inherited - sex linked recessive Inherited - autosomal recessive platelet defect Nosebleeds and gum bleeding are usually manifestations of which type of coagulation disorder? thrombosis

The toxin responsible for this syndrome is produced by E. coli O157:H7 Impaired neurological function is one of the primary symptoms 9:1 Which of the following ratios of blood to anticoagulant is acceptable for most coagulation procedures?

clotting factor disorder of factor XII 1:9 vascular disorder 5:1 platelet defect Bernard-Soulier syndrome A coagulation disorder commonly associated with umbilicus bleeding and post-circumcision bleeding is known as:

9:1

Idiopathic thrombocytopenic purpura

1:4 Calcium ions Platelet aggregation is dependent on the presence of:

Glanzmann's thrombasthenia

Calcium ions

von Willebrand's disease

Potassium

Bernard-Soulier syndrome converts fibrinogen to fibin Which of the following is one of the key roles of thrombin with respect to fibrinogen?

Sodium citrate

activates factor V and VIII

Magnesium Female carrier A man with hemophilia A and an unaffected female can produce a:

converts fibrinogen to fibin

Female with hemophilia A

releases fibrin split products

Female carrier

changes fibrinogen to prothrombin Factor XIII Which of the clotting factors is not a protease?

Male carrier

Factor IX

Male with hemophilia A Spleen Which organ is responsible for sheltering 20% of the total platelet volume in the circulation?

Factor VII Kidney Factor XIII Liver Factor II The toxin responsible for this syndrome is produced by E. coli O157:H7 In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

Spleen Adrenal gland Fibrinogen

The main substrate of the coagulation system is:

GP Ib

Collagen

GP IIb/IIIa

Calcium

vWF

ADP

cadmium Ca2+ and thromboplastin In the prothrombin test, the patient's citrated plasma is combined with:

Fibrinogen Petechiae A decreased platelet count is most often anticipated when a patient demonstrates:

Phospholipids

Thrombosis

Ca2+ and actin

Petechiae

Thromboplastin only

Hemarthrosis

Ca2+ and thromboplastin Fibrinogen The substrate upon which the coagulation cascade is centered is:

Glossitis II, VII, IX, and X The prothrombin group of factors consists of factors:

Vitamin K

III, VIII, IX, and X

Fibrinogen

II, VII, IX, and X

Thrombin

XI, XII, prekallikrein, and HMWK

Fibrin Hemophilia B Christmas disease is another name for:

I, V, VIII, and XIII Fitzgerald factor Which factor is involved in contact activation?

Factor VII deficiency

Fibrinogen

Hemophilia B

Factor II

Hemophilia A

Fitzgerald factor

von Willebrand's disease Vasoconstriction The first response of a cut vessel is:

Factor X Factor V Which factor is measured by both the PT and the aPTT?

Activation of the intrinsic pathway Platelet aggregation

Factor XIII Vasoconstriction Factor V Factor VIII Factor IX GP IIb/IIIa Platelet aggregation cannot occur if __________ is absent.

Vasodilation 7 to 10 days The average lifespan of a platelet in a normal adult is: 7 to 10 days 18 to 21 days

Sickle cell disease 1 to 5 days TTP 5 to 7 days Bone marrow Platelets are synthesized in the:

Polycythemia vera (PCV)

Bone marrow

Acute leukemia Sodium citrate The anticoagulant of choice for routine coagulation procedure is:

Lymph glands

Sodium citrate

Spleen Adhesion, aggregation, release, stabilization There are four phases in regards to platelet function. The correct order of occurrence from the beginning to end is:

Sodium oxalate

Liver

Adhesion, release, aggregation, stabilization Adhesion, aggregation, release, stabilization

Sodium fluoride Heparin Neonatal alloimmune thrombocytopenia Several days after birth, a baby boy develops the following symptoms, petechiae, purpura, and skin hemorrhage. The platelet count is 18,000. The most likely explanation is:

Aggregation, adhesion, stabilization, release Drug-induced thrombocytopenia Release, aggregation, adhesion, stabilization Factor VIII The only clotting factor not synthesized exclusively by the liver is: Factor IX Factor VII

Neonatal alloimmune thrombocytopenia Secondary thrombocytopenia Neonatal DIC Platelet count Which of the following test results is normal in a patient with classic von Willebrand's disease?

Factor VIII Platelet count Factor V Factor X deficiency The following laboratory results have been obtained for a 40-year-old woman: PT=20 seconds (reference range is 11 to 15 seconds), aPTT=50 seconds (reference range is 22 to 40 seconds), and thrombin time=18 seconds (reference range is 11 to 15 seconds). What factor deficiency is most likely?

Factor VIII and vWF levels Bleeding time

Factor X deficiency

Activated partial thromboplastin time fibrinolysis, plasmin The process of fibrin degradation is called ______________ and is controlled by the enzyme ____________.

Factor VIII deficiency

fibrinolysis, protease

Factor VII deficiency

fibrinolysis, plasmin

Factor XIII deficiency Polycythemia vera (PCV) Which of the following conditions may result in primary thrombocytosis?

fibrination, plasmin fibrination, protease Activating thromboplastin

All of the following are functions of thrombin except:

Activating thromboplastin

WBC (X109/L) = 4.5, RBC (X1012/L) = 6.7, Hgb (g/dL) = 16.7, Hct(%) = 48.2, MCV (Fl) = 89, MCH (pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt (X109/L) = 253

Simulating platelets to product PGI2

WBC only

Initiating the platelet release reaction 10 to 15 seconds The reference range for a thrombin time is:

WBC and RBC

10 to 15 seconds

RBC only Platelets, Hgb and Hct If the following results are for a 75 year old female patient, which are out of range LOW?

Activating factors V and VIII

40 to 60 seconds

Hgb and Hct

100 to 120 seconds 20 to 40 seconds Fibrin degradation The D-dimer test measures:

WBC (X109/L) = 9.5, RBC (X1012/L) = 5.7, Hgb (g/dL) = 10.7, Hct(%) = 28.2, MCV (Fl) = 89, MCH (pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt (X109/L) = 53

Fibrinogen deposition

RBC only

Fibrin deposition

Platelets, Hgb and Hct

Fibrinogen degradation

RBC, Hct and MCV

Fibrin degradation 200 to 400 mg/dL The reference range for fibrinogen is:

RBC and Hgb WBC and RBC If the following results are for a 50 year old male patient, which are out of range HIGH?

600 to 750 mg/dL 200 to 400 mg/dL

WBC (X109/L) = 11.5, RBC (X1012/L) = 6.7, Hgb (g/dL) = 16.7, Hct(%) = 48.2

100 to 200 mg/dL

Hgb and Hct

400 to 600 mg/dL RBC and Hgb If the following results are for a 10 year old male patient, which are out of range HIGH?

RBC and Hgb

WBC (X109/L) = 4.5, RBC (X1012/L) = 6.7, Hgb (g/dL) = 16.7, Hct(%) = 48.2

RBC only WBC and RBC RBC, Hct and Hgb If the following results are for a 25 year old female patient, which are out of range LOW?

RBC and Hgb Hgb and Hct WBC and RBC RBC only WBC only If the following results are for a 62 year old male patient, which are out of range LOW?

WBC (X109/L) = 9.5, RBC (X1012/L) = 3.7, Hgb (g/dL) = 10.7, Hct(%) = 28.2, MCV (Fl) = 89, MCH (pg) = 29.2, MCHC (%) = 35.2, RDW (%) = 13.4, Plt (X109/L) = 253 RBC only Platelets, Hgb and Hct

RBC and Hgb

Plasmin

RBC, Hct and Hgb high The patient's thrombin time is 20 seconds. Is this high, low, or normal?

Tissue-type plasminogen activator (tPA)

high

Thrombin Inactivates factors XII, XI, and IX in the presence of antithrombin The anticoagulant known as heparin:

low

Chelates calcium

my head hurts and I can no longer answer questions

Inactivates factors XII, XI, and IX in the presence of antithrombin

normal high The patient's prothrombin time is 14 seconds. Is this high, low, or normal?

Degrades antithrombin activity Inhibits PF3 activity Prevents activation of factor X by VIIa Tissue factor pathway inhibitor (TFPI):

high Prevents activation of factor X by VIIa low Activates the common pathway my head hurts and I can no longer answer questions normal yes The patient's APTT time is 35 seconds. Is this normal?

Inhibits fibrinolysis Inhibits the kallikrein proteins Factors I, V, VII, XIII The fibrinogen group of coagulation factors include: Factors XI and XII

I have no idea Factos II, VII, IX, X no Factors III, VIII, IX, X my head hurts and I can no longer answer questions yes Thromboxane A2 The vasoconstrictor substance released from the platelets at the site of injury is:

Factors I, V, VII, XIII Plasminogen activator system Fibrinolysis is controlled by the: Thrombin feedback activation system Feedback inhibition system

Thrombin Intrinsic system Thromboxane A2 Adenosine diphosphate Prostacyclin Thrombin Which of the following is not a component of the fibrinolytic system? Urokinase

Plasminogen activator system All of the above Therapeutic thrombolytic agents include: tPA Streptokinase Urokinase

All of the above Epistaxis A decreased platelet count is most often anticipated when a patient demonstrates:

Thrombocytopenia with absent radii Alpha granule defect Which defect characterizes Gray's syndrome? Coagulation defect

Genitourinary bleeding Platelet adhesion defect Rectal bleeding Dense granule defect Severe hemorrhage Epistaxis Aspirin Which of the following causes irreeversible inactivation of platelets?

Alpha granule defect GP IIb/IIIa, GP Ib/IX The autoantibody generated in ITP is directed against: Collagen

Vitamin K GP IIb/IIIa, GP Ib/IX Aspirin vWF Heparin Coumadin Hermansky-Pudlak syndrome A platelet release defect in which there is a severe deficiency of dense granules in platelets is known as:

Fibrinopeptides A and B Factor assays Which of the following is the most useful in differentiating hemophilia A from hemophilia B? Factor assays

Bernard-Soulier syndrome

Activated partial thromboplastin time

Chediak-Higashi syndrome

A familial pattern of inheritance

Hermansky-Pudlak syndrome

Patient's history Administration of prothrombin complex concentrate Treatment of patients with factor II, VII, or X deficiency consists of:

Wiskott-Aldrich syndrome Ristocetin co-factor activity The single best predictive assay for von Willebrand factor is:

Administration of whole blood

Ristocetin co-factor activity

Administration of cryoprecipitate

aPTT

Administration of FFP

Bleeding time

Administration of prothrombin complex concentrate Factor XIII deficiency Keloid scar formation is most commonly associated with:

Platelet count Chronic idiopathic thrombocytopenic purpura Which of the following is an autoimmune thrombocytopenic disorder process?

Factor IX deficiency

von Willebrand's disease

Factor XII deficiency

Hemolytic uremic syndrome

Factor XIII deficiency

Chronic idiopathic thrombocytopenic purpura

Factor VIII deficiency

Factor V Factor V Leiden is a genetic mutation of: The prothrombin molecule Factov V Hemophilia A Factor IV Factor VIII deficient plasma When performing a factor VIII activity assay, a patient's plasma is mixed with: Plasma with a high concentration of factor VIII Normal patient's plasma Normal control plasma Factor VIII deficient plasma Fresh frozen plasma The most suitable product for treatment of factor VIII deficiency is: Factor VIII concentrate Factor V Leiden Fresh frozen plasma` Prothrombin complex concentrate Prolonged APTT, normal PT Which results are associated with a Factor IX Deficiency? Normal PT and APTT Prolonged PT, normal APTT Prolonged PT, and APTT Prolonged APTT, normal PT Megakaryocyte Identify the large blue cell in this bone marrow smear. Reed Sternberg cell Nucleated red cell Megakaryocyte Myeloblast