Patofisiologi Sle
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Patofisiologi SLE Gen Resesif + faktor Lingkungan Respon imun abnormal Pembentukan terus-menerus subset autoantibodi dan KI KI ↑ SFM tidak mampu mengolah KI dengan normal Jar. Idotip anti idiotip tidak dapat menekan sel T dan B yang hiperaktif Mekanisme toleransi normal menonaktifkan limfosit T & B terganggu gg.vaskuler : trombosis aliran ke organ & jaringan
ginjal
GI
Ig mengendap
aliran ke usus ↓ trombosis
Di glomelorus menstimulus Nefritis
kulit
s.simpatis Distensi lambung
pada p.darah ruam gg.integritas
Perasaan kenyang Anoreksia Intake nutrisi ↓ BB ↓ Resti gg.pemenuhan nutrisi Kurang dr kebutuhan
kulit
muskulo aliran nutrisi dan O2 ↓ pegal-pegal gg.mobilitas
vaskulitis
hematologi anemia
mata vaskulis retina
ginjal
GI
Ig mengendap
aliran ke usus ↓ trombosis
Di glomelorus menstimulus Nefritis
kulit
s.simpatis Distensi lambung
pada p.darah ruam gg.integritas
Perasaan kenyang Anoreksia Intake nutrisi ↓ BB ↓ Resti gg.pemenuhan nutrisi Kurang dr kebutuhan
kulit
muskulo aliran nutrisi dan O2 ↓ pegal-pegal gg.mobilitas
vaskulitis
hematologi anemia
mata vaskulis retina
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